<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:15f0a110-59f2-42f0-9115-6b31974c3ad9,g:89ef47be-3b2e-4ebd-bcc2-008a9e253c9c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://seer.bio/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="seer-20211231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://seer.bio/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_0fdebe2a-4194-4db4-adb6-73a3b1691f59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_ffee0a93-a275-4e51-aad9-294802fdd14f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0fdebe2a-4194-4db4-adb6-73a3b1691f59" xlink:to="loc_us-gaap_Liabilities_ffee0a93-a275-4e51-aad9-294802fdd14f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_af007c6c-ad40-4b8a-a493-420826699930" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0fdebe2a-4194-4db4-adb6-73a3b1691f59" xlink:to="loc_us-gaap_CommitmentsAndContingencies_af007c6c-ad40-4b8a-a493-420826699930" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_70a88f3d-41d5-4019-91bb-9be2de9b6f42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0fdebe2a-4194-4db4-adb6-73a3b1691f59" xlink:to="loc_us-gaap_StockholdersEquity_70a88f3d-41d5-4019-91bb-9be2de9b6f42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_23aea294-4809-4b7d-87cc-0df735b0612c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_e6817809-3449-47e5-9139-6c33be58b897" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_23aea294-4809-4b7d-87cc-0df735b0612c" xlink:to="loc_us-gaap_AssetsCurrent_e6817809-3449-47e5-9139-6c33be58b897" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_bb737e90-64a7-4cef-8bcd-d5d74272af13" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_23aea294-4809-4b7d-87cc-0df735b0612c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_bb737e90-64a7-4cef-8bcd-d5d74272af13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_f32de186-6b88-4574-bd07-6f917db78614" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_23aea294-4809-4b7d-87cc-0df735b0612c" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_f32de186-6b88-4574-bd07-6f917db78614" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_36b1f0a5-8321-42f8-a835-982b56a90cc9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_23aea294-4809-4b7d-87cc-0df735b0612c" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_36b1f0a5-8321-42f8-a835-982b56a90cc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_ea56df19-d194-44f4-a163-f471e51d5f04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_23aea294-4809-4b7d-87cc-0df735b0612c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_ea56df19-d194-44f4-a163-f471e51d5f04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_ae485c28-cc36-41f9-bf86-ce8e10167d63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_23aea294-4809-4b7d-87cc-0df735b0612c" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_ae485c28-cc36-41f9-bf86-ce8e10167d63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_bc4e0976-67a0-4cf8-8f9b-ffafcce40a7f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_bc4e0976-67a0-4cf8-8f9b-ffafcce40a7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_b71c548f-6e92-4abb-af7a-2f9fd7016009" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_b71c548f-6e92-4abb-af7a-2f9fd7016009" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_73bb7659-527b-433e-ae7e-2cdb6c45f664" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_73bb7659-527b-433e-ae7e-2cdb6c45f664" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueFromRelatedPartiesCurrent_ed191fa7-c680-4d23-a008-ed1cb2de8834" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DueFromRelatedPartiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:to="loc_us-gaap_DueFromRelatedPartiesCurrent_ed191fa7-c680-4d23-a008-ed1cb2de8834" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_89eefc9b-6e06-4a7c-9ab6-5d32f25106a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsAndOtherReceivablesNetCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:to="loc_us-gaap_AccountsAndOtherReceivablesNetCurrent_89eefc9b-6e06-4a7c-9ab6-5d32f25106a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_eceb6aef-9304-4272-b824-839f8a0745bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:to="loc_us-gaap_InventoryNet_eceb6aef-9304-4272-b824-839f8a0745bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_47676fa1-0341-45ca-9669-bfbadbe7710b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_23a49c75-f95c-481e-814b-4bcd6a12c318" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_47676fa1-0341-45ca-9669-bfbadbe7710b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_338d2b56-5f1a-4e22-9008-11280805e967" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_2dfa42f9-b167-497e-aa2a-a08cb0e7c027" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_338d2b56-5f1a-4e22-9008-11280805e967" xlink:to="loc_us-gaap_PreferredStockValue_2dfa42f9-b167-497e-aa2a-a08cb0e7c027" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_612afd9f-15fd-46df-a710-8013b4f01601" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_338d2b56-5f1a-4e22-9008-11280805e967" xlink:to="loc_us-gaap_CommonStockValue_612afd9f-15fd-46df-a710-8013b4f01601" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_3c8ef220-0752-4b61-bb23-b99dcbf9bfb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_338d2b56-5f1a-4e22-9008-11280805e967" xlink:to="loc_us-gaap_AdditionalPaidInCapital_3c8ef220-0752-4b61-bb23-b99dcbf9bfb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_00f53256-33a1-4498-ad2b-776c1e95e98d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_338d2b56-5f1a-4e22-9008-11280805e967" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_00f53256-33a1-4498-ad2b-776c1e95e98d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c1c2e75c-3811-47c5-ae77-155d6e914dc0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_338d2b56-5f1a-4e22-9008-11280805e967" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_c1c2e75c-3811-47c5-ae77-155d6e914dc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_c6a54c92-d536-4eed-8dbd-8ae90d39579e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_6735db09-6a6a-49c1-95ff-aab0f9dfd9d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c6a54c92-d536-4eed-8dbd-8ae90d39579e" xlink:to="loc_us-gaap_ContractWithCustomerLiability_6735db09-6a6a-49c1-95ff-aab0f9dfd9d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_49936a34-5683-47c9-a36a-e4a518c0a398" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c6a54c92-d536-4eed-8dbd-8ae90d39579e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_49936a34-5683-47c9-a36a-e4a518c0a398" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_b2a5e98c-d751-4a2b-8d86-bfbf615f5a96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c6a54c92-d536-4eed-8dbd-8ae90d39579e" xlink:to="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_b2a5e98c-d751-4a2b-8d86-bfbf615f5a96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedLiabilitiesResearchAndDevelopmentCostsCurrent_f2767b81-b394-4878-be21-f40477a1c6f2" xlink:href="seer-20211231.xsd#seer_AccruedLiabilitiesResearchAndDevelopmentCostsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c6a54c92-d536-4eed-8dbd-8ae90d39579e" xlink:to="loc_seer_AccruedLiabilitiesResearchAndDevelopmentCostsCurrent_f2767b81-b394-4878-be21-f40477a1c6f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_52f9540b-3baf-47da-a551-99dd28922ef2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c6a54c92-d536-4eed-8dbd-8ae90d39579e" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_52f9540b-3baf-47da-a551-99dd28922ef2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRentCreditCurrent_6518335c-ef43-4d95-94c7-a5bc2ed2749a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredRentCreditCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c6a54c92-d536-4eed-8dbd-8ae90d39579e" xlink:to="loc_us-gaap_DeferredRentCreditCurrent_6518335c-ef43-4d95-94c7-a5bc2ed2749a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_c8b09477-bcc6-41b0-a035-cb59a76b90e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_d29adb32-e127-4ba3-963a-8a85afcbcfee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c8b09477-bcc6-41b0-a035-cb59a76b90e8" xlink:to="loc_us-gaap_LiabilitiesCurrent_d29adb32-e127-4ba3-963a-8a85afcbcfee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_8746776d-c958-4c6b-92a9-de7bdb852df7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c8b09477-bcc6-41b0-a035-cb59a76b90e8" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_8746776d-c958-4c6b-92a9-de7bdb852df7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_ac9ecdbb-a7fa-48f4-ba2d-885c8158bc52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c8b09477-bcc6-41b0-a035-cb59a76b90e8" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_ac9ecdbb-a7fa-48f4-ba2d-885c8158bc52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRentCreditNoncurrent_68ab1d78-0fe7-466a-841e-2b26867c9862" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredRentCreditNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c8b09477-bcc6-41b0-a035-cb59a76b90e8" xlink:to="loc_us-gaap_DeferredRentCreditNoncurrent_68ab1d78-0fe7-466a-841e-2b26867c9862" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="seer-20211231.xsd#ConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://seer.bio/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_0da048ab-6afb-41cd-ab17-9e1190fdb5f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ac85afbb-01cc-48f1-84c3-057f12cc7d81" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_0da048ab-6afb-41cd-ab17-9e1190fdb5f2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ac85afbb-01cc-48f1-84c3-057f12cc7d81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_4132a65c-be42-49f5-8eb5-eda7ed2ec6f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_0da048ab-6afb-41cd-ab17-9e1190fdb5f2" xlink:to="loc_us-gaap_CostOfRevenue_4132a65c-be42-49f5-8eb5-eda7ed2ec6f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_28473c2f-b11e-40b9-9168-ba5abe63ea9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_a87fb791-99b8-4f32-8a31-0e736783135e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_28473c2f-b11e-40b9-9168-ba5abe63ea9d" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_a87fb791-99b8-4f32-8a31-0e736783135e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_eeddbc50-1ab1-4fe0-b98e-b551aabf079e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_28473c2f-b11e-40b9-9168-ba5abe63ea9d" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_eeddbc50-1ab1-4fe0-b98e-b551aabf079e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_6a4900e7-52f1-489d-a64b-edeabf8dd534" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_b0b55dfd-e1d3-43e9-b5be-1fbeacba1cde" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_6a4900e7-52f1-489d-a64b-edeabf8dd534" xlink:to="loc_us-gaap_InvestmentIncomeInterest_b0b55dfd-e1d3-43e9-b5be-1fbeacba1cde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingExpense_3af4e826-7ef1-4bdd-9704-3d5efc8324aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_6a4900e7-52f1-489d-a64b-edeabf8dd534" xlink:to="loc_us-gaap_OtherNonoperatingExpense_3af4e826-7ef1-4bdd-9704-3d5efc8324aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_f75b7121-9fde-45c1-be53-5ff84e7fd7d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_6a4900e7-52f1-489d-a64b-edeabf8dd534" xlink:to="loc_us-gaap_InterestExpense_f75b7121-9fde-45c1-be53-5ff84e7fd7d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_722b00e5-fd01-4d82-8205-984d3d520ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_541e86ad-df81-442d-b417-cf871de652dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_722b00e5-fd01-4d82-8205-984d3d520ba6" xlink:to="loc_us-gaap_OperatingIncomeLoss_541e86ad-df81-442d-b417-cf871de652dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_44e4fa93-86cd-409c-aa04-a6310c22269b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_722b00e5-fd01-4d82-8205-984d3d520ba6" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_44e4fa93-86cd-409c-aa04-a6310c22269b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_cd52c78d-9a0a-401d-9ce0-a84573a818b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_92eab0ca-46a4-437a-92f8-7e2d74b7d8e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_cd52c78d-9a0a-401d-9ce0-a84573a818b5" xlink:to="loc_us-gaap_NetIncomeLoss_92eab0ca-46a4-437a-92f8-7e2d74b7d8e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_74792077-c407-423b-b789-8305c5c27a93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_cd52c78d-9a0a-401d-9ce0-a84573a818b5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_74792077-c407-423b-b789-8305c5c27a93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_61a780b2-c54e-4ea1-b3a0-33edb367e06f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_1c36442b-cd46-452e-9720-9f15d471692e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_61a780b2-c54e-4ea1-b3a0-33edb367e06f" xlink:to="loc_us-gaap_GrossProfit_1c36442b-cd46-452e-9720-9f15d471692e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_1ce62276-cd83-4e6c-adba-39e40a5c6088" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_61a780b2-c54e-4ea1-b3a0-33edb367e06f" xlink:to="loc_us-gaap_OperatingExpenses_1ce62276-cd83-4e6c-adba-39e40a5c6088" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="seer-20211231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://seer.bio/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_719c9cad-8553-4d41-9b0a-c63ae220bbd8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_719c9cad-8553-4d41-9b0a-c63ae220bbd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_ProceedsFromReturnOnProfit_88de6c61-519b-42ca-8d72-ec47d848b43d" xlink:href="seer-20211231.xsd#seer_ProceedsFromReturnOnProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_seer_ProceedsFromReturnOnProfit_88de6c61-519b-42ca-8d72-ec47d848b43d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3d3bde51-759f-4c9e-ba53-14629e4e484d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3d3bde51-759f-4c9e-ba53-14629e4e484d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_a59ed511-2161-4dca-b156-9828cf97c079" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_a59ed511-2161-4dca-b156-9828cf97c079" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfConvertiblePreferredStock_fe424e50-3561-4f42-b766-c5ac2ae597a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfConvertiblePreferredStock"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfConvertiblePreferredStock_fe424e50-3561-4f42-b766-c5ac2ae597a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_6925f653-f0d1-47cd-86c7-5b1addd7bef6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_us-gaap_ProceedsFromIssuanceInitialPublicOffering_6925f653-f0d1-47cd-86c7-5b1addd7bef6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_48a238ee-d034-47e3-ac54-bc6ba54b9cc0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_48a238ee-d034-47e3-ac54-bc6ba54b9cc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_d347f443-9588-4927-893b-ef971f948fc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2618e6e6-7978-408d-acea-dcb40505dbfd" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_d347f443-9588-4927-893b-ef971f948fc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94ff5cee-9e73-420b-af5d-62e0c41655e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_d752ef4f-395c-4749-9a5b-c4073a9c4ce9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94ff5cee-9e73-420b-af5d-62e0c41655e8" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_d752ef4f-395c-4749-9a5b-c4073a9c4ce9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_2be3a345-2e35-4b2c-8386-ecdc0368759d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94ff5cee-9e73-420b-af5d-62e0c41655e8" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_2be3a345-2e35-4b2c-8386-ecdc0368759d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_5687aea6-3be4-4ab5-af28-efabc03e0c22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94ff5cee-9e73-420b-af5d-62e0c41655e8" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_5687aea6-3be4-4ab5-af28-efabc03e0c22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_5e4bfdc9-9522-4788-a0b6-7447f6686877" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_94ff5cee-9e73-420b-af5d-62e0c41655e8" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_5e4bfdc9-9522-4788-a0b6-7447f6686877" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_adf8c66a-4334-489d-abac-2497d66ed6db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2b43aae0-c882-4d50-833c-8c34b8526459" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_adf8c66a-4334-489d-abac-2497d66ed6db" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2b43aae0-c882-4d50-833c-8c34b8526459" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_aa7a2049-1f86-408c-8c6d-eb5ce2e6c5f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_adf8c66a-4334-489d-abac-2497d66ed6db" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_aa7a2049-1f86-408c-8c6d-eb5ce2e6c5f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ba0e6aed-498e-4cf6-afd3-45711cce50a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_adf8c66a-4334-489d-abac-2497d66ed6db" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ba0e6aed-498e-4cf6-afd3-45711cce50a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d208fdf7-cb63-4a00-8db7-1dede8bde0a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_NetIncomeLoss_d208fdf7-cb63-4a00-8db7-1dede8bde0a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_3b6f8108-277b-4fe9-a1c9-d5cd620c9b90" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_ShareBasedCompensation_3b6f8108-277b-4fe9-a1c9-d5cd620c9b90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDepreciationAndAmortization_293b6f07-66f7-40bc-b8f4-7a28d506fbe1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherDepreciationAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_OtherDepreciationAndAmortization_293b6f07-66f7-40bc-b8f4-7a28d506fbe1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_56e7b431-2b9d-4af8-8c31-5a535fe7e188" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_56e7b431-2b9d-4af8-8c31-5a535fe7e188" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_9b2dee98-dd0f-40a5-9696-22448c16f14b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_9b2dee98-dd0f-40a5-9696-22448c16f14b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_dd888fe3-50e6-4390-9e13-5705cdc52edb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_OperatingLeaseExpense_dd888fe3-50e6-4390-9e13-5705cdc52edb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_30dfdcaf-32bd-42bf-baad-c6233737c4cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_30dfdcaf-32bd-42bf-baad-c6233737c4cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties_ffe557f2-f6f8-4f03-8c61-6efff9aebab0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties_ffe557f2-f6f8-4f03-8c61-6efff9aebab0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_975f08e8-33f6-4447-be90-6d589043c86e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherReceivables"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherReceivables_975f08e8-33f6-4447-be90-6d589043c86e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_17082fc6-f56b-4d93-9f61-779268114285" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_17082fc6-f56b-4d93-9f61-779268114285" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_d2615fca-42d7-4978-8f64-f6abd528c558" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_d2615fca-42d7-4978-8f64-f6abd528c558" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_909ae2ab-5f17-494b-83db-e4829bf6f666" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_909ae2ab-5f17-494b-83db-e4829bf6f666" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_7f147134-e58e-4e33-8cb3-04a173d9e8ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_7f147134-e58e-4e33-8cb3-04a173d9e8ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_9694867a-effc-47d4-9139-d3db408895ac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_9694867a-effc-47d4-9139-d3db408895ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredLiabilities_86101c51-5d19-4473-9ec2-5393beb0008c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredLiabilities"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredLiabilities_86101c51-5d19-4473-9ec2-5393beb0008c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_454f5fbb-6f50-4258-8d56-49d1ec3a84f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_454f5fbb-6f50-4258-8d56-49d1ec3a84f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_IncreaseDecreaseInAccruedResearchAndDevelopment_4abcde81-afe0-4cb1-8973-b461a6b0f740" xlink:href="seer-20211231.xsd#seer_IncreaseDecreaseInAccruedResearchAndDevelopment"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_seer_IncreaseDecreaseInAccruedResearchAndDevelopment_4abcde81-afe0-4cb1-8973-b461a6b0f740" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_35392e6d-fdeb-47de-9f56-fcf799f07b02" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_35392e6d-fdeb-47de-9f56-fcf799f07b02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_49a2efcc-bb85-4b2e-a0f5-16eb06e90758" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_14c377f0-8d05-457f-9f50-e7ceae157828" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_49a2efcc-bb85-4b2e-a0f5-16eb06e90758" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c214159a-f9a1-4a6e-a39a-c863c40693b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_637faf06-1109-47a6-a409-dde40ddc72f7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c214159a-f9a1-4a6e-a39a-c863c40693b1" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_637faf06-1109-47a6-a409-dde40ddc72f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_f4f12761-cbfc-4009-bfca-3d30f30510c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_c214159a-f9a1-4a6e-a39a-c863c40693b1" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_f4f12761-cbfc-4009-bfca-3d30f30510c4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsAssetsMeasuredonRecurringBasisDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#FairValueMeasurementsandFairValueofFinancialInstrumentsAssetsMeasuredonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsAssetsMeasuredonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_82085daf-dc3b-4b16-842e-b942e6f54fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_961b6af8-6020-4140-8c1b-6a7f522bc781" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_82085daf-dc3b-4b16-842e-b942e6f54fb9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_961b6af8-6020-4140-8c1b-6a7f522bc781" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_a990a22f-126f-4b5f-bfa3-8ff27c1ab145" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_82085daf-dc3b-4b16-842e-b942e6f54fb9" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_a990a22f-126f-4b5f-bfa3-8ff27c1ab145" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d9738693-fb00-4528-b53e-0f34b7e1938e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_cdfc6835-dfd3-49b6-9cec-5fdb74232ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d9738693-fb00-4528-b53e-0f34b7e1938e" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_cdfc6835-dfd3-49b6-9cec-5fdb74232ffc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_74b20e6d-40c1-4e43-a13d-ab607d4edd83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d9738693-fb00-4528-b53e-0f34b7e1938e" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_74b20e6d-40c1-4e43-a13d-ab607d4edd83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_58887477-e1c4-4344-b3c0-d2bda4200879" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d9738693-fb00-4528-b53e-0f34b7e1938e" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_58887477-e1c4-4344-b3c0-d2bda4200879" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofInventoryDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#OtherFinancialStatementInformationScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_36666f00-63a7-4fec-9eb6-cd7d422886a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_882dc1e8-f151-4253-88b4-017fdb406116" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_36666f00-63a7-4fec-9eb6-cd7d422886a0" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_882dc1e8-f151-4253-88b4-017fdb406116" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_eae3937b-0d3a-44c9-aa1f-120046f4d7de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_36666f00-63a7-4fec-9eb6-cd7d422886a0" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_eae3937b-0d3a-44c9-aa1f-120046f4d7de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_f614dfd9-3193-40dc-84a9-a0d97b32da97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_36666f00-63a7-4fec-9eb6-cd7d422886a0" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_f614dfd9-3193-40dc-84a9-a0d97b32da97" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ec65b074-cae9-4b61-972f-dfb55d1be21e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_4e901b8e-fedc-4e60-9ca1-3224956acc32" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_ec65b074-cae9-4b61-972f-dfb55d1be21e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_4e901b8e-fedc-4e60-9ca1-3224956acc32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_b04f3ce6-838d-4614-b312-9d92187563a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_ec65b074-cae9-4b61-972f-dfb55d1be21e" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_b04f3ce6-838d-4614-b312-9d92187563a0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofAccruedCompensationDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#OtherFinancialStatementInformationScheduleofAccruedCompensationDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofAccruedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_177a6ae6-ea57-4bdf-8925-b7a03439b6d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedCompensation_cdeaa987-57d8-45e6-8b8b-f7141ea6fa4c" xlink:href="seer-20211231.xsd#seer_AccruedCompensation"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_177a6ae6-ea57-4bdf-8925-b7a03439b6d1" xlink:to="loc_seer_AccruedCompensation_cdeaa987-57d8-45e6-8b8b-f7141ea6fa4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_RestrictedStockLiability_d30c5c58-b3ee-44fe-a48a-69e0bda5d11c" xlink:href="seer-20211231.xsd#seer_RestrictedStockLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_177a6ae6-ea57-4bdf-8925-b7a03439b6d1" xlink:to="loc_seer_RestrictedStockLiability_d30c5c58-b3ee-44fe-a48a-69e0bda5d11c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_09106890-d71e-4a8d-8e27-053d2d498f06" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_177a6ae6-ea57-4bdf-8925-b7a03439b6d1" xlink:to="loc_us-gaap_TaxesPayableCurrent_09106890-d71e-4a8d-8e27-053d2d498f06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_bdddff39-95ad-4dfa-a240-a0655598dd52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_177a6ae6-ea57-4bdf-8925-b7a03439b6d1" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_bdddff39-95ad-4dfa-a240-a0655598dd52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedPropertyAndEquipment_4a0ca996-ea3f-4f72-a188-06e78a3bc484" xlink:href="seer-20211231.xsd#seer_AccruedPropertyAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_177a6ae6-ea57-4bdf-8925-b7a03439b6d1" xlink:to="loc_seer_AccruedPropertyAndEquipment_4a0ca996-ea3f-4f72-a188-06e78a3bc484" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_c435b393-c60f-4bf9-b0ec-09ba6c6672e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAndNoncurrent_177a6ae6-ea57-4bdf-8925-b7a03439b6d1" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_c435b393-c60f-4bf9-b0ec-09ba6c6672e2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CommitmentandContingenciesMinimumCommitmentsDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#CommitmentandContingenciesMinimumCommitmentsDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CommitmentandContingenciesMinimumCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_c1e1e87f-16f5-4bfa-9ad1-c0d1714f009d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_05b44a23-c2d5-4c58-a947-c7558d265a19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_c1e1e87f-16f5-4bfa-9ad1-c0d1714f009d" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_05b44a23-c2d5-4c58-a947-c7558d265a19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_79fb95ba-7544-488b-b37e-4a0573cc88da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_c1e1e87f-16f5-4bfa-9ad1-c0d1714f009d" xlink:to="loc_us-gaap_OperatingLeaseLiability_79fb95ba-7544-488b-b37e-4a0573cc88da" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CommitmentandContingenciesMinimumCommitmentsDetails_1" xlink:type="simple" xlink:href="seer-20211231.xsd#CommitmentandContingenciesMinimumCommitmentsDetails_1"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CommitmentandContingenciesMinimumCommitmentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d8af8b04-3e7b-49f5-931e-56eb344555a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_c88dd290-6214-4ba8-b0f9-fae5dc0a65d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d8af8b04-3e7b-49f5-931e-56eb344555a3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_c88dd290-6214-4ba8-b0f9-fae5dc0a65d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_80d36564-1162-49b7-8893-6fb893649952" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d8af8b04-3e7b-49f5-931e-56eb344555a3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_80d36564-1162-49b7-8893-6fb893649952" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_c6c7e6fc-4b7e-4c07-82b2-51994553bb83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d8af8b04-3e7b-49f5-931e-56eb344555a3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_c6c7e6fc-4b7e-4c07-82b2-51994553bb83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_ed9aeb21-2d47-43b5-912d-e475cad02709" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d8af8b04-3e7b-49f5-931e-56eb344555a3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_ed9aeb21-2d47-43b5-912d-e475cad02709" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_7ea75f52-9804-4596-9611-60112f1637c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d8af8b04-3e7b-49f5-931e-56eb344555a3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_7ea75f52-9804-4596-9611-60112f1637c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_4d5d5009-e5fb-47ab-9f72-027ce343538b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d8af8b04-3e7b-49f5-931e-56eb344555a3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_4d5d5009-e5fb-47ab-9f72-027ce343538b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CommitmentsAndContingenciesMinimumCommitmentsUnderPreviousAccountingStandardsDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#CommitmentsAndContingenciesMinimumCommitmentsUnderPreviousAccountingStandardsDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CommitmentsAndContingenciesMinimumCommitmentsUnderPreviousAccountingStandardsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ae5b024c-a4b7-46cb-b7a9-3a0fc1b571a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_6ba97cea-4ebd-4941-8fee-38e8e390acff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ae5b024c-a4b7-46cb-b7a9-3a0fc1b571a3" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_6ba97cea-4ebd-4941-8fee-38e8e390acff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_4f56a7c1-f0e9-4d80-b182-9ffd181e2fd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ae5b024c-a4b7-46cb-b7a9-3a0fc1b571a3" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_4f56a7c1-f0e9-4d80-b182-9ffd181e2fd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_681f5f73-f378-4c11-9db2-b2778c569a3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ae5b024c-a4b7-46cb-b7a9-3a0fc1b571a3" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_681f5f73-f378-4c11-9db2-b2778c569a3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_203a10cd-85c6-45b5-91ca-a21612e7948b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ae5b024c-a4b7-46cb-b7a9-3a0fc1b571a3" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_203a10cd-85c6-45b5-91ca-a21612e7948b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_d4516c00-1e6a-4446-9fbe-03d7c9bb075a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ae5b024c-a4b7-46cb-b7a9-3a0fc1b571a3" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_d4516c00-1e6a-4446-9fbe-03d7c9bb075a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_4e345a6e-6910-4001-bae1-fbfc84f991fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_ae5b024c-a4b7-46cb-b7a9-3a0fc1b571a3" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_4e345a6e-6910-4001-bae1-fbfc84f991fc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/IncomeTaxesScheduleofIncomeTaxExpenseDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#IncomeTaxesScheduleofIncomeTaxExpenseDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/IncomeTaxesScheduleofIncomeTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_EffectiveIncomeTaxRateReconciliationGainOnRelatedPartyTransactionAmount_5fa271ed-9683-4f8a-a8f0-33da00622a22" xlink:href="seer-20211231.xsd#seer_EffectiveIncomeTaxRateReconciliationGainOnRelatedPartyTransactionAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_seer_EffectiveIncomeTaxRateReconciliationGainOnRelatedPartyTransactionAmount_5fa271ed-9683-4f8a-a8f0-33da00622a22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_542721aa-8151-4d21-bfbc-10a16f4ce0f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_542721aa-8151-4d21-bfbc-10a16f4ce0f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_564c8c43-31e9-48e9-9784-47100f77ef83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_564c8c43-31e9-48e9-9784-47100f77ef83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_63eb33e5-3e42-4b3d-96ab-44a63d74d014" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_63eb33e5-3e42-4b3d-96ab-44a63d74d014" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_10a103fc-61b8-4051-a277-e056a7a7a49e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_10a103fc-61b8-4051-a277-e056a7a7a49e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_3ff0335f-c43f-4002-a5e0-82320fc3ddde" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpense"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_3ff0335f-c43f-4002-a5e0-82320fc3ddde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_03e0bec1-02fc-4c63-9fe3-10dd1a9e3e67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_03e0bec1-02fc-4c63-9fe3-10dd1a9e3e67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_d8ae8a43-efea-41c5-868c-cff8cd5b4a4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_d8ae8a43-efea-41c5-868c-cff8cd5b4a4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_c3b007fb-c1c4-4486-9f02-6f721904f37d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a34a7989-bee9-4ad9-af2b-be0b33291ffa" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_c3b007fb-c1c4-4486-9f02-6f721904f37d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="seer-20211231.xsd#IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilities_772bfc50-8bf2-421b-b22d-77e2970a18d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_7af717a9-cfca-46be-bc60-804fd5343368" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_772bfc50-8bf2-421b-b22d-77e2970a18d3" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_7af717a9-cfca-46be-bc60-804fd5343368" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_d20c8cf8-24c8-4b4a-bb2e-dfdd02bb252e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_772bfc50-8bf2-421b-b22d-77e2970a18d3" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_d20c8cf8-24c8-4b4a-bb2e-dfdd02bb252e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_fc5c3626-2324-4de0-bba0-834c3e415e8d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_1addde21-1f3c-43cd-8283-d9650f510c53" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_fc5c3626-2324-4de0-bba0-834c3e415e8d" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_1addde21-1f3c-43cd-8283-d9650f510c53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_63538e0f-d35c-4fa6-92ea-4f090c49d905" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_fc5c3626-2324-4de0-bba0-834c3e415e8d" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_63538e0f-d35c-4fa6-92ea-4f090c49d905" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_2490d538-abc4-4084-98a5-c92f5bae13d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_fc5c3626-2324-4de0-bba0-834c3e415e8d" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_2490d538-abc4-4084-98a5-c92f5bae13d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_f151813d-4ad5-450a-a85e-fc0abec34251" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_fc5c3626-2324-4de0-bba0-834c3e415e8d" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_f151813d-4ad5-450a-a85e-fc0abec34251" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_1027a5c1-8468-4a13-b89f-fc53fa54f761" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_fc5c3626-2324-4de0-bba0-834c3e415e8d" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_1027a5c1-8468-4a13-b89f-fc53fa54f761" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_DeferredTaxAssetsLeaseLiabilities_465a59b4-3d98-4ab0-8f1d-2cf1ca6a6a60" xlink:href="seer-20211231.xsd#seer_DeferredTaxAssetsLeaseLiabilities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_fc5c3626-2324-4de0-bba0-834c3e415e8d" xlink:to="loc_seer_DeferredTaxAssetsLeaseLiabilities_465a59b4-3d98-4ab0-8f1d-2cf1ca6a6a60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_25fbe474-d6d2-4ca1-bcd9-421f185db6d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_d955d453-ee36-4697-8c1e-a66ed83b7f1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_25fbe474-d6d2-4ca1-bcd9-421f185db6d9" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_d955d453-ee36-4697-8c1e-a66ed83b7f1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_DeferredTaxLiabilitiesFixedAssetsAndIntangibleAssets_9976e027-c086-4c15-aa68-d6d3366b3749" xlink:href="seer-20211231.xsd#seer_DeferredTaxLiabilitiesFixedAssetsAndIntangibleAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_25fbe474-d6d2-4ca1-bcd9-421f185db6d9" xlink:to="loc_seer_DeferredTaxLiabilitiesFixedAssetsAndIntangibleAssets_9976e027-c086-4c15-aa68-d6d3366b3749" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_17875223-0753-4653-b62e-bc2bc668e7f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_60dfcbd2-64bf-4de8-90e7-ff460a8bc7b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_17875223-0753-4653-b62e-bc2bc668e7f1" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_60dfcbd2-64bf-4de8-90e7-ff460a8bc7b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_dc4135a4-0236-45e4-9a3f-80ec84faa894" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_17875223-0753-4653-b62e-bc2bc668e7f1" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_dc4135a4-0236-45e4-9a3f-80ec84faa894" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
