<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:0239ba9d-5b65-4e40-9458-988b62f84900,g:94aba11e-1af8-46a5-84ad-c207ef3b7785-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://seer.bio/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="seer-20230331.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_35c3511e-a494-4964-ad8f-5d5afb4517ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_14917877-2c30-47a7-8552-b32ff78dd514" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_35c3511e-a494-4964-ad8f-5d5afb4517ee" xlink:to="loc_us-gaap_CommitmentsAndContingencies_14917877-2c30-47a7-8552-b32ff78dd514" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c864216f-2f69-4032-8948-8e981c153ec5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_35c3511e-a494-4964-ad8f-5d5afb4517ee" xlink:to="loc_us-gaap_StockholdersEquity_c864216f-2f69-4032-8948-8e981c153ec5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_1e8a1e63-de31-4bc0-a4ab-93c4ee3cd3d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_35c3511e-a494-4964-ad8f-5d5afb4517ee" xlink:to="loc_us-gaap_Liabilities_1e8a1e63-de31-4bc0-a4ab-93c4ee3cd3d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_a1bd848a-589d-49d4-b619-e799b9a13e98" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_dc5240b7-235e-4fe2-9e71-27bc6c65d76f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a1bd848a-589d-49d4-b619-e799b9a13e98" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_dc5240b7-235e-4fe2-9e71-27bc6c65d76f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_b45b0c18-15ee-423f-9638-e1ec57db6266" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a1bd848a-589d-49d4-b619-e799b9a13e98" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_b45b0c18-15ee-423f-9638-e1ec57db6266" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_01fcbaf1-4c04-4a5d-9621-87a5211a8a54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_a1bd848a-589d-49d4-b619-e799b9a13e98" xlink:to="loc_us-gaap_LiabilitiesCurrent_01fcbaf1-4c04-4a5d-9621-87a5211a8a54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_21e4b6e8-7d6b-472d-9aee-af4da7ae582b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_9dad5089-5073-4604-96c4-937b4f0140ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_21e4b6e8-7d6b-472d-9aee-af4da7ae582b" xlink:to="loc_us-gaap_AccountsPayableCurrentAndNoncurrent_9dad5089-5073-4604-96c4-937b4f0140ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_11cfc5c4-f9f5-4b05-bf5d-7a9dc57cf5a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_21e4b6e8-7d6b-472d-9aee-af4da7ae582b" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_11cfc5c4-f9f5-4b05-bf5d-7a9dc57cf5a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_0c5126c7-0d0c-4ef5-9542-b7e025737804" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_21e4b6e8-7d6b-472d-9aee-af4da7ae582b" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_0c5126c7-0d0c-4ef5-9542-b7e025737804" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e47fe3bd-0007-4d12-8da8-58ba718cc946" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_21e4b6e8-7d6b-472d-9aee-af4da7ae582b" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e47fe3bd-0007-4d12-8da8-58ba718cc946" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_96bfbd1f-203c-49a5-b089-996540c6b566" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_21e4b6e8-7d6b-472d-9aee-af4da7ae582b" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_96bfbd1f-203c-49a5-b089-996540c6b566" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_a22dfa51-2ba3-49ca-a067-f1bef5fc027f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_bdbf81dd-9f3f-4bb3-8648-652a8a9ac0eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a22dfa51-2ba3-49ca-a067-f1bef5fc027f" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_bdbf81dd-9f3f-4bb3-8648-652a8a9ac0eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_14994327-fd55-41ec-bcb7-bad8b520a2f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a22dfa51-2ba3-49ca-a067-f1bef5fc027f" xlink:to="loc_us-gaap_AdditionalPaidInCapital_14994327-fd55-41ec-bcb7-bad8b520a2f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_80ae50c7-5572-4faa-8515-36e9c0d5218f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a22dfa51-2ba3-49ca-a067-f1bef5fc027f" xlink:to="loc_us-gaap_CommonStockValue_80ae50c7-5572-4faa-8515-36e9c0d5218f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_5edb7fe7-9215-45b9-bf01-f675ea603b8b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a22dfa51-2ba3-49ca-a067-f1bef5fc027f" xlink:to="loc_us-gaap_PreferredStockValue_5edb7fe7-9215-45b9-bf01-f675ea603b8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_118334f0-14ef-46a9-b0a8-5361b6190299" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_a22dfa51-2ba3-49ca-a067-f1bef5fc027f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_118334f0-14ef-46a9-b0a8-5361b6190299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_68b619cf-fd3f-4254-b0a9-0026ea0fceda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_68b619cf-fd3f-4254-b0a9-0026ea0fceda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_a9a4e144-1221-4cfa-a2d4-6a537c85cb47" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:to="loc_us-gaap_InventoryNet_a9a4e144-1221-4cfa-a2d4-6a537c85cb47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_84c13fee-f6e3-49be-b6ac-74b62d316eb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_84c13fee-f6e3-49be-b6ac-74b62d316eb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_3ba6afa0-faf8-4406-a293-609bb92cfc42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_3ba6afa0-faf8-4406-a293-609bb92cfc42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueFromRelatedPartiesCurrent_ebd64bfc-1842-4f4a-a7c5-dff1566b3461" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueFromRelatedPartiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:to="loc_us-gaap_DueFromRelatedPartiesCurrent_ebd64bfc-1842-4f4a-a7c5-dff1566b3461" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_e695e6eb-efa7-4414-9267-64a2715ed763" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_e695e6eb-efa7-4414-9267-64a2715ed763" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_3062578f-01ac-4e1e-b8e8-d4a04e85e68e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_00c95fb3-6fbc-4d74-8a77-5d9315e447fa" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_3062578f-01ac-4e1e-b8e8-d4a04e85e68e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_b492192b-b5d5-4cfc-859d-201588ccd269" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_111ba701-1c0e-4ded-bd8d-65ae09f05083" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b492192b-b5d5-4cfc-859d-201588ccd269" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_111ba701-1c0e-4ded-bd8d-65ae09f05083" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_fdbc729c-5012-427a-a5f5-16de944a456b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b492192b-b5d5-4cfc-859d-201588ccd269" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_fdbc729c-5012-427a-a5f5-16de944a456b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_d6754d0d-e763-4774-84ad-21883e77ef20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b492192b-b5d5-4cfc-859d-201588ccd269" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_d6754d0d-e763-4774-84ad-21883e77ef20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_dc217af9-85ab-439b-af03-4b630deeba06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b492192b-b5d5-4cfc-859d-201588ccd269" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_dc217af9-85ab-439b-af03-4b630deeba06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_9a9e189a-4848-4cda-8acc-f8a03ef8919a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b492192b-b5d5-4cfc-859d-201588ccd269" xlink:to="loc_us-gaap_AssetsCurrent_9a9e189a-4848-4cda-8acc-f8a03ef8919a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_fe486278-3bba-422f-9fb8-dc58b7f337cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_b492192b-b5d5-4cfc-859d-201588ccd269" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_fe486278-3bba-422f-9fb8-dc58b7f337cf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="seer-20230331.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_970c29b8-c24b-4fb4-8b0b-5409d7de5ae8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_f72af368-533b-425b-ab54-6f0f4eaa930e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_970c29b8-c24b-4fb4-8b0b-5409d7de5ae8" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_f72af368-533b-425b-ab54-6f0f4eaa930e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_5f6d5939-ace2-4e4c-a506-362440d0a449" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_970c29b8-c24b-4fb4-8b0b-5409d7de5ae8" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_5f6d5939-ace2-4e4c-a506-362440d0a449" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_be70cf35-3ead-4cb1-a630-2cb275efad97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_e2be87d3-e31d-4376-b590-94a72eb3e774" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_be70cf35-3ead-4cb1-a630-2cb275efad97" xlink:to="loc_us-gaap_OperatingIncomeLoss_e2be87d3-e31d-4376-b590-94a72eb3e774" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_33785633-9496-472a-994a-0a272a3e125e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_be70cf35-3ead-4cb1-a630-2cb275efad97" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_33785633-9496-472a-994a-0a272a3e125e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_923479fe-f76a-4496-9cb3-a06d605fc835" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_36935301-9ea2-4fa9-b4d9-6447d881c4be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_923479fe-f76a-4496-9cb3-a06d605fc835" xlink:to="loc_us-gaap_NetIncomeLoss_36935301-9ea2-4fa9-b4d9-6447d881c4be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_8e26c2f2-abac-4b4f-8d7b-9ca3cdd8d82d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_923479fe-f76a-4496-9cb3-a06d605fc835" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_8e26c2f2-abac-4b4f-8d7b-9ca3cdd8d82d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_5e8cae72-3e0a-47c4-bca7-24c0a9bf5c9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_9501008e-6cab-475d-9456-9869a5b987f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_5e8cae72-3e0a-47c4-bca7-24c0a9bf5c9b" xlink:to="loc_us-gaap_CostOfRevenue_9501008e-6cab-475d-9456-9869a5b987f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8a8602af-01e2-4ee6-a0cf-f49778a993d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_5e8cae72-3e0a-47c4-bca7-24c0a9bf5c9b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8a8602af-01e2-4ee6-a0cf-f49778a993d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_7825b023-6f9a-4965-b7bc-50b8774ab549" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_1ca6b146-c858-45f9-90e8-bad6a5374329" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_7825b023-6f9a-4965-b7bc-50b8774ab549" xlink:to="loc_us-gaap_OperatingExpenses_1ca6b146-c858-45f9-90e8-bad6a5374329" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_6657fe5b-da7b-4c8c-94c4-833e611a892f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_7825b023-6f9a-4965-b7bc-50b8774ab549" xlink:to="loc_us-gaap_GrossProfit_6657fe5b-da7b-4c8c-94c4-833e611a892f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_e5b4735f-6f34-4f5f-8e73-3f52ab8bf0ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingExpense_075c8fc4-d09d-4001-9a74-a03964056a66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_e5b4735f-6f34-4f5f-8e73-3f52ab8bf0ef" xlink:to="loc_us-gaap_OtherNonoperatingExpense_075c8fc4-d09d-4001-9a74-a03964056a66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_6f37185c-2598-491d-9768-569df0465f52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_e5b4735f-6f34-4f5f-8e73-3f52ab8bf0ef" xlink:to="loc_us-gaap_InvestmentIncomeInterest_6f37185c-2598-491d-9768-569df0465f52" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="seer-20230331.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://seer.bio/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ab47de64-5bab-4414-8bb8-623672f901c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_b31d2682-44da-4311-b600-5511b79d3122" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ab47de64-5bab-4414-8bb8-623672f901c2" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_b31d2682-44da-4311-b600-5511b79d3122" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_519a6f51-4571-4691-8cf2-eb481b43cad9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ab47de64-5bab-4414-8bb8-623672f901c2" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_519a6f51-4571-4691-8cf2-eb481b43cad9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_0f17faea-a673-4967-bee0-e69a290f2529" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ab47de64-5bab-4414-8bb8-623672f901c2" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_0f17faea-a673-4967-bee0-e69a290f2529" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_847189af-45da-47b6-875e-366287f100f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ab47de64-5bab-4414-8bb8-623672f901c2" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_847189af-45da-47b6-875e-366287f100f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_575cbb00-1bb9-4ce2-b0ba-1b57d1c656a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_575cbb00-1bb9-4ce2-b0ba-1b57d1c656a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_ee9bb5cf-18e1-4853-9ecf-b124fa05da5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_ee9bb5cf-18e1-4853-9ecf-b124fa05da5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherCurrentLiabilities_b0bdfe08-6a83-47ef-818b-08f55627d765" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherCurrentLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherCurrentLiabilities_b0bdfe08-6a83-47ef-818b-08f55627d765" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_ac53d85e-b582-4508-b945-2d1521f8f48b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_ShareBasedCompensation_ac53d85e-b582-4508-b945-2d1521f8f48b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_ff684fe3-4b96-4120-ae04-e297fa8b4cab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsAndOtherReceivables_ff684fe3-4b96-4120-ae04-e297fa8b4cab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_35fdc877-eb0f-49bc-acf8-426b0e6ad36a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_InventoryWriteDown_35fdc877-eb0f-49bc-acf8-426b0e6ad36a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_98594f3d-8672-44e0-816d-082144c66ac7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_98594f3d-8672-44e0-816d-082144c66ac7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_fa03cee1-9b10-4041-9f41-beefbcb26ed2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherReceivables"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherReceivables_fa03cee1-9b10-4041-9f41-beefbcb26ed2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_b123abeb-9cf8-46be-95c4-10ff89b78636" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_OperatingLeaseExpense_b123abeb-9cf8-46be-95c4-10ff89b78636" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_6c87711a-09e3-4a07-bebb-98a28fe7bc04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_6c87711a-09e3-4a07-bebb-98a28fe7bc04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_a6e990b8-3c54-41b6-a2f2-575a9e93db10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_a6e990b8-3c54-41b6-a2f2-575a9e93db10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_56d7ff28-e686-4705-95d4-b416220731e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_56d7ff28-e686-4705-95d4-b416220731e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties_1e0e583b-1311-40a9-a988-df09594f8148" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties_1e0e583b-1311-40a9-a988-df09594f8148" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_2a2a77b1-e7fe-4ffc-a40e-1f442c6f67ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_2a2a77b1-e7fe-4ffc-a40e-1f442c6f67ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_4f4918f1-0fe7-465e-8fc6-456002c0cfb7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_NetIncomeLoss_4f4918f1-0fe7-465e-8fc6-456002c0cfb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_77008520-3836-46a5-abdc-975320fd9b0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_77008520-3836-46a5-abdc-975320fd9b0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDepreciationAndAmortization_a25e9772-4421-4f53-abb6-a769993c0f18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherDepreciationAndAmortization"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_OtherDepreciationAndAmortization_a25e9772-4421-4f53-abb6-a769993c0f18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_f2d4b770-3970-4546-92c8-1122c968f356" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ffa0b32-1fd5-4eb7-b93a-2fabf64abb60" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_f2d4b770-3970-4546-92c8-1122c968f356" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_27f4fe1a-67c2-490b-8547-4f4b835d3361" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_df762357-3c27-46c4-8778-45e10dd87da7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_27f4fe1a-67c2-490b-8547-4f4b835d3361" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_df762357-3c27-46c4-8778-45e10dd87da7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_9a613f9a-8457-4947-99e2-56c47fc72a77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_27f4fe1a-67c2-490b-8547-4f4b835d3361" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_9a613f9a-8457-4947-99e2-56c47fc72a77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_86c80c51-2f3b-43fd-9dc6-6584454c0c8c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_53988b72-8989-4984-a5d2-8e0fb90a9246" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_86c80c51-2f3b-43fd-9dc6-6584454c0c8c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_53988b72-8989-4984-a5d2-8e0fb90a9246" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b967e6fc-aff1-4a42-94c4-7507af12e0f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_86c80c51-2f3b-43fd-9dc6-6584454c0c8c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b967e6fc-aff1-4a42-94c4-7507af12e0f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_564ae902-cbdc-498e-8d32-61ff3e00def5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_86c80c51-2f3b-43fd-9dc6-6584454c0c8c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_564ae902-cbdc-498e-8d32-61ff3e00def5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/SummaryofSignificantAccountingPoliciesandBasisofPresentationCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_7d8f5e38-e9a0-4a71-a2f5-e44f656d219b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_91ccaa15-2d28-4ab3-a03a-d874eea3fb74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_7d8f5e38-e9a0-4a71-a2f5-e44f656d219b" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_91ccaa15-2d28-4ab3-a03a-d874eea3fb74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3bbab2fc-3a63-423a-85bf-aa47f3b8aea5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_7d8f5e38-e9a0-4a71-a2f5-e44f656d219b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_3bbab2fc-3a63-423a-85bf-aa47f3b8aea5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsFinancialAssetsMeasuredatFairValueOnaRecurringBasisDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#FairValueMeasurementsandFairValueofFinancialInstrumentsFinancialAssetsMeasuredatFairValueOnaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsFinancialAssetsMeasuredatFairValueOnaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_11d69954-60a9-499a-b251-e1d60be4d00c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_af112fcd-4103-449e-b7d8-8cabac64c64a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_11d69954-60a9-499a-b251-e1d60be4d00c" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_af112fcd-4103-449e-b7d8-8cabac64c64a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_634abfa6-25f1-4d02-be4d-7097696980e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_11d69954-60a9-499a-b251-e1d60be4d00c" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_634abfa6-25f1-4d02-be4d-7097696980e3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/FairValueMeasurementsandFairValueofFinancialInstrumentsUnrealizedGainLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_710666e0-98e8-45e0-bac0-fa476b1ec8ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d101127b-ced6-433a-91fd-d4d6fffcc7af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_710666e0-98e8-45e0-bac0-fa476b1ec8ef" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d101127b-ced6-433a-91fd-d4d6fffcc7af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_89d1256f-4727-4640-9d16-520e6a1cd00b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_710666e0-98e8-45e0-bac0-fa476b1ec8ef" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_89d1256f-4727-4640-9d16-520e6a1cd00b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3b0eea10-cb9a-4ef6-9fb0-9940eccf48c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_710666e0-98e8-45e0-bac0-fa476b1ec8ef" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3b0eea10-cb9a-4ef6-9fb0-9940eccf48c6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofInventoryDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#OtherFinancialStatementInformationScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_ee9dd613-d3f4-4616-8912-e6ebd80c84b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_e3b6d44e-cad5-493b-8e41-0f210c636fef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee9dd613-d3f4-4616-8912-e6ebd80c84b3" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_e3b6d44e-cad5-493b-8e41-0f210c636fef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_fce93676-6514-47f9-9a21-18cfa7f7f71e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee9dd613-d3f4-4616-8912-e6ebd80c84b3" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_fce93676-6514-47f9-9a21-18cfa7f7f71e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_869f62b5-61d4-49eb-af4b-577193f2cc7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ee9dd613-d3f4-4616-8912-e6ebd80c84b3" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_869f62b5-61d4-49eb-af4b-577193f2cc7e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_d7f64657-f039-4641-9428-2230c85fe362" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_cc9b4c41-09d0-4ce9-9c59-89080ac93ea9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_d7f64657-f039-4641-9428-2230c85fe362" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_cc9b4c41-09d0-4ce9-9c59-89080ac93ea9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1b853b59-127b-4b7a-8982-760fe95add9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_d7f64657-f039-4641-9428-2230c85fe362" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1b853b59-127b-4b7a-8982-760fe95add9d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/OtherFinancialStatementInformationScheduleofAccruedCompensationDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#OtherFinancialStatementInformationScheduleofAccruedCompensationDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/OtherFinancialStatementInformationScheduleofAccruedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_aaa35645-11f2-42e9-8f98-f9325ea946f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_3b882fb8-1746-4377-8b65-5dcbc37b79d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_aaa35645-11f2-42e9-8f98-f9325ea946f8" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrentAndNoncurrent_3b882fb8-1746-4377-8b65-5dcbc37b79d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_b4362458-f756-4433-8ffb-99d1d60d5264" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_aaa35645-11f2-42e9-8f98-f9325ea946f8" xlink:to="loc_us-gaap_TaxesPayableCurrent_b4362458-f756-4433-8ffb-99d1d60d5264" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_8fda7f8a-ac87-4c59-a353-2a0b59bc024b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_aaa35645-11f2-42e9-8f98-f9325ea946f8" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_8fda7f8a-ac87-4c59-a353-2a0b59bc024b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedCompensation_5d5c15ff-c574-4f92-98ad-7a044917e1c4" xlink:href="seer-20230331.xsd#seer_AccruedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_aaa35645-11f2-42e9-8f98-f9325ea946f8" xlink:to="loc_seer_AccruedCompensation_5d5c15ff-c574-4f92-98ad-7a044917e1c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedResearchAndDevelopment_849261a0-3c7c-472b-b2d1-a54164e542b0" xlink:href="seer-20230331.xsd#seer_AccruedResearchAndDevelopment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_aaa35645-11f2-42e9-8f98-f9325ea946f8" xlink:to="loc_seer_AccruedResearchAndDevelopment_849261a0-3c7c-472b-b2d1-a54164e542b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_AccruedPropertyAndEquipment_32077ee1-b6e4-4ef8-88dd-df3ff3907c61" xlink:href="seer-20230331.xsd#seer_AccruedPropertyAndEquipment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_aaa35645-11f2-42e9-8f98-f9325ea946f8" xlink:to="loc_seer_AccruedPropertyAndEquipment_32077ee1-b6e4-4ef8-88dd-df3ff3907c61" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/LeasesComponentsofLeaseCostDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#LeasesComponentsofLeaseCostDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/LeasesComponentsofLeaseCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_da914e46-402d-4567-8917-8a6490d3c07d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_4bc43265-2012-4c26-83d1-74d687176b69" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_da914e46-402d-4567-8917-8a6490d3c07d" xlink:to="loc_us-gaap_VariableLeaseCost_4bc43265-2012-4c26-83d1-74d687176b69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_90fdcc60-24ce-4805-ad5d-4e002085b064" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_da914e46-402d-4567-8917-8a6490d3c07d" xlink:to="loc_us-gaap_OperatingLeaseCost_90fdcc60-24ce-4805-ad5d-4e002085b064" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_743a35c3-7e53-41d9-bbc8-1c8a1c3190c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_da914e46-402d-4567-8917-8a6490d3c07d" xlink:to="loc_us-gaap_ShortTermLeaseCost_743a35c3-7e53-41d9-bbc8-1c8a1c3190c9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/LeasesFutureMinimumCommitmentsDetails" xlink:type="simple" xlink:href="seer-20230331.xsd#LeasesFutureMinimumCommitmentsDetails"/>
  <link:calculationLink xlink:role="http://seer.bio/role/LeasesFutureMinimumCommitmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_19c8259c-7e1b-4de2-a22d-da43b7021aac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_9d7a41d0-17c2-48c9-87ff-4d2e0d80ca8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_19c8259c-7e1b-4de2-a22d-da43b7021aac" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_9d7a41d0-17c2-48c9-87ff-4d2e0d80ca8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_a993cf75-bb86-4c25-bfb3-6c05ad92991d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_19c8259c-7e1b-4de2-a22d-da43b7021aac" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_a993cf75-bb86-4c25-bfb3-6c05ad92991d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_69c9f6e4-7ca9-4bec-b3fc-26b90f64e7bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_19c8259c-7e1b-4de2-a22d-da43b7021aac" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_69c9f6e4-7ca9-4bec-b3fc-26b90f64e7bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_seer_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_b9617ba2-a8ee-4682-8908-098bb0da8d64" xlink:href="seer-20230331.xsd#seer_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_19c8259c-7e1b-4de2-a22d-da43b7021aac" xlink:to="loc_seer_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_b9617ba2-a8ee-4682-8908-098bb0da8d64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_1f6bb6cd-73e6-4aa9-b3ae-3ba2a2559c53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_19c8259c-7e1b-4de2-a22d-da43b7021aac" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_1f6bb6cd-73e6-4aa9-b3ae-3ba2a2559c53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_d02184f5-631c-4992-82f1-f4e569875ae5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_19c8259c-7e1b-4de2-a22d-da43b7021aac" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_d02184f5-631c-4992-82f1-f4e569875ae5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://seer.bio/role/LeasesFutureMinimumCommitmentsDetails_1" xlink:type="simple" xlink:href="seer-20230331.xsd#LeasesFutureMinimumCommitmentsDetails_1"/>
  <link:calculationLink xlink:role="http://seer.bio/role/LeasesFutureMinimumCommitmentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_36c4de19-a136-4197-aa98-16b2cc5773e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_9d8d10db-ef6e-4216-b787-2264c204dfa6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_36c4de19-a136-4197-aa98-16b2cc5773e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_9d8d10db-ef6e-4216-b787-2264c204dfa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_9e301bca-de8c-4b1c-8e64-887b9f5602e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_36c4de19-a136-4197-aa98-16b2cc5773e4" xlink:to="loc_us-gaap_OperatingLeaseLiability_9e301bca-de8c-4b1c-8e64-887b9f5602e4" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
